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KMID : 0351619730140020341
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Kyungpook Medical Journal
1973 Volume.14 No. 2 p.341 ~ p.344
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Synthesis of Protein and Cellular Transport of alpha-aminoisobutyric Acid-^(14)C in Carbon Tetrachloride Induced Cirrhotic Rat Liver
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Abstract
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The purpose of this work was to study the change of the activity of protein synthesis and cellular transport of amino acid in rat liver induced severe cirrhosis by a long term administration of carbon tetrachloride.
Sprague-Dowley rats were injected subcutaneously twice weekly with a 50% solution of carbon tetrachloride in olive oil for 13 weeks. Twenty four rats developed severe cirrhosis of the liver were used for the experiment.
The incorporation of amino acid mixed-^(14)C into liver protein decrcased by 26% whereas the uptake of alpha aminoisobutyric acid-^(14)C in liver tissue was reduced by 60% in the cirrhotic liver compared to control rats.
Above fact revealed that, in the cirrhotic liver, the damage in liver protein synthesis was less significant though the cellular transport of amino acid was strikingly inhibited.
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